| Related citation: | Zhixia Teng,Maozu Guo,Xiaoyan Liu,Jin Li,Qiguo Dai,Chunyu Wang.Construct Protein-Protein Interaction Network by Mining Domain-Domain Interactions[J].Journal of Harbin Institute Of Technology(New Series),2016,23(4):27-36.DOI:10.11916/j.issn.1005-9113.2016.04.005. |
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| Author Name | Affiliation | | Zhixia Teng | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
Department of Information Management and Information System, Northeast Forestry University, Harbin 150040, China | | Maozu Guo | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | | Xiaoyan Liu | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | | Jin Li | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | | Qiguo Dai | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | | Chunyu Wang | Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China |
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| Abstract: |
| Domain-domain interactions are important clues to inferring protein-protein interactions. Although about 8 000 domain-domain interactions are discovered so far, they are just the tip of the iceberg. Because domains are conservative and commonplace in proteins, domain-domain interactions are discovered based on pairs of domains which significantly co-exist in proteins. Meanwhile, it is realized that: (1) domain-domain interactions may exist within the same proteins or across different proteins; (2) only the domain-domain interactions across different proteins can mediate interactions between proteins; (3) domains have biases to interact with other domains. And then, a novel method is put forward to construct protein-protein interaction network by using domain-domain interactions. The method is validated by experiments and compared with the state-of-art methods in the field. The experimental results suggest that the method is reasonable and effectiveness on constructing Protein-protein interactions network. |
| Key words: protein-protein interaction domain-domain interaction statistical significance test |
| DOI：10.11916/j.issn.1005-9113.2016.04.005 |
| Clc Number:TP391, Q811.4 |
| Fund: |
