| 引用本文: | 董宇涵,辜鹏程,张子阳,张丽娟,白燕.肌腱仿生用定向PLLA微纳米纤维的静电纺丝工艺参数研究[J].材料科学与工艺,2022,30(5):10-17.DOI:10.11951/j.issn.1005-0299.20210335. |
| DONG Yuhan,GU Pengcheng,ZHANG Ziyang,ZHANG Lijuan,BAI Yan.Electrospinning process parameters of directional PLLA micro/nano fibers for tendon bionics[J].Materials Science and Technology,2022,30(5):10-17.DOI:10.11951/j.issn.1005-0299.20210335. |
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| 摘要: |
| 采用左旋聚乳酸(PLLA)为基材研究静电纺丝工艺过程对聚乳酸纤维形貌和性能的影响,主要包括环境湿度、纺丝溶液浓度、接收转速、收集距离、注射泵推注速度、附加电压等过程参数。结果表明,接收转速与纺丝液浓度分别是影响纤维定向排列程度和纤维直径的最主要因素,其次是接收距离、环境湿度、推注速度。当聚乳酸-氯仿溶液聚合物质量浓度为80 mg/mL、纺丝电压为25 kV、接收距离为20 cm、注射泵推注速度为0.3 μL/s以及接收转速为1500 r/min时,纤维取向性良好,平均直径为(0.94±0.21) μm,可达到模拟肌腱组织天然细胞外基质结构的要求。 |
| 关键词: 组织工程 肌腱 静电纺丝 左旋聚乳酸 定向纤维膜 工艺参数 |
| DOI：10.11951/j.issn.1005-0299.20210335 |
| 分类号:R318; Q81 |
| 文献标识码:A |
| 基金项目:重庆市科委面上项目(cstc2017jcyjAX0029);重庆医科大学大学生创新实验项目(SRIEP202194);重庆医科大学药学院学术骨干项目(YXY2019XSGG10);重庆医科大学药学院优秀本科生培养项目. |
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| Electrospinning process parameters of directional PLLA micro/nano fibers for tendon bionics |
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DONG Yuhan1, GU Pengcheng2, ZHANG Ziyang1, ZHANG Lijuan1, BAI Yan1
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(1. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;2. Experimental Teaching Center, Chongqing Medical University, Chongqing 400016, China)
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| Abstract: |
| Poly (L-lactic acid) (PLLA) was used to explore the effects of electrospinning parameters on the morphology and properties of fibers, including environmental humidity, polymer solution concentration, rotation speed of receiver, needle-collector distance, injection pump pushing speed, and spinning voltage. Results show that the rotation speed and polymer solution concentration were the most important factors affecting the directional arrangement and diameter of fibers, followed by needle-collector distance, environmental humidity, and pushing speed. Fibers with diameter of (0.94±0.21) μm and good orientation were successfully prepared under conditions of 80 mg/mL polymer solution concentration, 25 kV spinning voltage, 20 cm needle-collector distance, 0.3 μL/s injection pump pushing speed, and 1 500 r/min rotation speed, which could meet the requirements of simulating the natural extracellular matrix structure of tendon tissues. |
| Key words: tissue engineer tendon electrospinning poly (L-lactic acid) directional fiber membrane process parameters |
