| 引用本文: | 吴明松,张玉玲,李绍峰,冉治霖,李百祥,黄君礼.亚氯酸盐对大鼠仔鼠的运动神经毒理学影响[J].哈尔滨工业大学学报,2012,44(10):53.DOI:10.11918/j.issn.0367-6234.2012.10.011 |
| WU Ming-song,ZHANG Yu-ling,LI Shao-feng,RAN Zhi-lin,LI Bai-xiang,HUANG Jun-li.Motor neurimotor toxicological effect of chlorite on the offspring rats[J].Journal of Harbin Institute of Technology,2012,44(10):53.DOI:10.11918/j.issn.0367-6234.2012.10.011 |
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| 亚氯酸盐对大鼠仔鼠的运动神经毒理学影响 |
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吴明松1,2, 张玉玲1,3, 李绍峰1,4, 冉治霖1, 李百祥5, 黄君礼1
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1.哈尔滨工业大学 城市水资源与水环境国家重点实验室, 150090 哈尔滨;2.东北大学 秦皇岛分校, 066004 河北 秦皇岛;3.华北电力大学 环境科学与工程学院, 071003 河北 保定;4.深圳职业技术学院 建筑与环境工程学院, 518055广东 深圳;5.哈尔滨医科大学 公共卫生学院,150006 哈尔滨
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| 摘要: |
| 为研究二氧化氯在水消毒过程中的主要副产物——亚氯酸盐对人体健康的影响,通过前肌力测试、脑部解剖学观察等运动神经毒理项目的测试等研究手段,研究30、120和 360 mg/L的亚氯酸盐对3代Wistar大鼠仔鼠运动神经系统的毒性．结果表明:亚氯酸钠对Wistar大鼠仔鼠并未表现出明显的毒理学效应和剂量效应关系,但部分360 mg/L剂量组仔鼠小脑发生病变; 对于Wistar大鼠仔鼠运动神经发育无明显副作用的剂量值为30 mg/L,亚氯酸盐在饮用水中的最大污染水平目标值为1.1 mg/L． |
| 关键词: 饮用水消毒 二氧化氯 亚氯酸钠 Wistar大鼠；运动神经毒理 |
| DOI：10.11918/j.issn.0367-6234.2012.10.011 |
| 分类号:TU993.1 |
| 基金项目:城市水资源与水环境国家重点实验室(哈尔滨工业大学)开放研究项目(ES200903)． |
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| Motor neurimotor toxicological effect of chlorite on the offspring rats |
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WU Ming-song1,2, ZHANG Yu-ling1,3, LI Shao-feng1,4, RAN Zhi-lin1, LI Bai-xiang5, HUANG Jun-li1
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1.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150090 Harbin, China;2.Northeastern University at Qinhuangdao, 066004 Qinhuangdao,Hebei, China;3.College of Environmental Science and Engineering, North China Electric Power University, 071003 Baoding, Hebei, China;4.Dept.of Architecture Engineering, Shenzhen Polytechnic Institute, 518055 Shenzhen, Guangdong, China;5.The Public Health School, Harbin Medical University, 150006 Harbin, China
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| Abstract: |
| To evaluate the effect of the byproduct of chlorine dioxide—chlorite on human, the neurimotor toxicological effects of sodium chlorite with the concentrations of 0,0 and 360 mg/L on the offspring rats was studied for three generation by using toxicological tests methods, such as muscle power and brain anatomical observation. The results show that no certain toxicological effect and dose-effect relationship in motor neurimotor system associated with chlorite was detected. Cerebellar lesions occurred in several offspring rat. No observed adverse effect was determined as the concentration is 30 mg/L, and the maximum contaminant level of chlorite in drinking water was 1.1 mg/L. |
| Key words: drinking water disinfection chlorine dioxide sodium chlorite Wistar rat motor neurimotor toxicology |
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