| 引用本文: | 田梦,孙雯,闫培生,马兴毅.多聚脱氧核糖核苷酸(PDRN)材料制备及其生物医药研究进展[J].材料科学与工艺,2025,33(1):8-21.DOI:10.11951/j.issn.1005-0299.20230254. |
| TIAN Meng,SUN Wen,YAN Peisheng,MA Xingyi.Preparation of polydeoxyribonucleotide (PDRN) materials and advances in biomedical research[J].Materials Science and Technology,2025,33(1):8-21.DOI:10.11951/j.issn.1005-0299.20230254. |
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| 多聚脱氧核糖核苷酸(PDRN)材料制备及其生物医药研究进展 |
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田梦1,孙雯2,闫培生3,马兴毅4,5,6
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(1.哈尔滨工业大学,哈尔滨 150006;2.山东省循证医学研究院,济南 250117;3.哈尔滨工业大学(威海),山东 威海 264209;4.哈尔滨工业大学(深圳),广东 深圳 518055;5.胞芯国际,济南 250117;6.发光分析与分子传感教育部重点实验室(西南大学),重庆 400715)
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| 摘要: |
| 生物材料是生物医学工程研究的关键要素之一,多聚脱氧核糖核苷酸(PDRN)是一类DNA衍生物,由于其具有组织修复、抗炎、促进伤口愈合、刺激血管生成、抗缺血损伤等多种药理活性,被广泛用于新的疗法和技术,以及开发人工生物替代系统等,用于支持、修复或替换受损的细胞、组织和器官等方面。本文综述了PDRN及其类似物的制备、生物医学应用、分子作用机制、载药体系等内容,且对PDRN在生物医学工程领域中存在的问题及未来发展潜能进行了探讨,为研究者们开发基于PDRN的新型技术与产品提供参考。 |
| 关键词: PDRN 分子机制 生物医学 药物负载与释放 PDRN/PN类似物 |
| DOI：10.11951/j.issn.1005-0299.20230254 |
| 分类号:R-1 |
| 文献标识码:A |
| 基金项目:深圳市自然科学基金资助项目(JCYJ20210324132815037, GXWD20220818171934001);广东省自然科学基金资助项目(2022A1515220158);广东省教育厅项目(2021KQNCX276, 2022ZDZX2065);中央高校基本科研业务费专项基金(No.HIT.OCEF.2022040);深圳市国际合作研究项目(GJHZ20220913143010018);国家自然科学基金资助项目(22371059, 82302346)、珠江人才计划(2021QN02Y120);中国博士后科学基金资助项目(2017M621664);钱江人才计划(QJD2002017);泰山产业领军人才(TSCY202006001);省优秀青年科学基金(2022HWYQ097);山东省生化分析重点实验室开放课题(SKLBA2302). |
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| Preparation of polydeoxyribonucleotide (PDRN) materials and advances in biomedical research |
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TIAN Meng1,SUN Wen2,YAN Peisheng3,MA Xingyi4,5,6
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(1.Harbin Institute of Technology, Harbin 150006, China; 2.Shandong Evidence Based Medicine Research Institute, Jinan 250117, China; 3.Harbin Institute of Technology(Weihai), Weihai 264209, China; 4.Harbin Institute of Technology(Shenzhen), Shenzhen 518055, China; 5.Biosen International, Jinan 250117, China; 6.Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Chongqing 400715, China)
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| Abstract: |
| Biomaterials are one of the key elements in biomedical engineering research. Polydeoxyribonucleotide (PDRN) is a type of DNA derivatives that have various pharmacological activities such as tissue repair, anti-inflammation, wound healing, stimulation of angiogenesis, and anti-ischemia properties. It is widely used in new therapies and technologies to develop artificial biological replacement systems to support, repair or replace damaged cells, tissues and organs. This article reviews the preparation, analogs, biomedical applications, molecular mechanism of action, drug loading system of PDRN and discusses the existing challenges and research trends of PDRN in the field of biomedical engineering. It provides a reference for researchers exploring novel technologies and products based on PDRN. |
| Key words: PDRN molecular mechanisms biomedicine drug carrier and release PDRN/PN analogues |
