| 引用本文: | 郭喜明,郭斌,陈磊,程树康.Fe3O4-10-HCPT及Fe3O4-HCPT@SiO2核壳纳米粒子的制备[J].哈尔滨工业大学学报,2015,47(3):93.DOI:10.11918/j.issn.0367-6234.2015.03.016 |
| GUO Ximing,GUO Bin,CHEN Lei,CHENG Shukang.Preparation of Fe3O4-10-HCPT and Fe3O4-HCPT@SiO2 core-shell nanoparticles[J].Journal of Harbin Institute of Technology,2015,47(3):93.DOI:10.11918/j.issn.0367-6234.2015.03.016 |
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| 摘要: |
| 为有效控制磁性四氧化三铁纳米粒子在水介质中的分散,防止其聚集．通过控制NaCl溶液的物质的量浓度,对比研究磁性四氧化三铁纳米粒子在超声前和超声后在盐中的分散情况. 实验结果表明,磁性四氧化三铁纳米粒子在0.4 mol／L的氯化钠中分散性最好,聚集度较小;进一步为了制备粒径均匀的复合磁性纳米载药粒子,通过调节10-羟基喜树碱溶液的pH,将10-羟基喜树碱和磁性纳米粒子制备成复合纳米粒子,并将其用二氧化硅包覆制备了复合载药纳米粒子,其复合纳米粒子的粒径大约为120 nm,结果显示通过该方法成功制备了理想的磁性纳米载药粒子． |
| 关键词: 磁流体 磁靶向系统 10-羟基喜树碱(10-HCPT) 药物释放 |
| DOI：10.11918/j.issn.0367-6234.2015.03.016 |
| 分类号:O6 |
| 基金项目:国家自然科学基金(51407046); 中央高校基本科研业务费专项基金(HIT.ICRST.2010012;HIT IBRSEM.2009003);科技部国际合作项目基金(2012DFR203320). |
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| Preparation of Fe3O4-10-HCPT and Fe3O4-HCPT@SiO2 core-shell nanoparticles |
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GUO Ximing1, GUO Bin2, CHEN Lei3, CHENG Shukang3
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(1. Shcool of Life of Science and Technology, Harbin Institute of Technology, 150001 Harbin, China; 2. School of Materials Science and Engineering, Harbin Institute of Technology, 150001 Harbin, China; 3. School of Electrical Engineering and Automation, Harbin Institute of Technology, 150001 Harbin, China)
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| Abstract: |
| To effectively control the dispersion and avoid the aggregate of Fe3O4 nanoparticles in the water, the dispersion of Fe3O4 nanoparticles was investigated before and after ultrasonic bath in different concentration of NaCl solution. The experimental results showed that the dispersion of Fe3O4 nanoparticles was little of aggeregates in the 0.4 mol／L NaCl solution. Furthermore, the magnetic Fe3O4-10-Hydroxycamptothecin compounds were prepared by refining pH values of 10-Hydroxycamptothecin system, and then the Fe3O4-HCPT@SiO2 core-shell structural nanoparticles were prepared, of which the diameter of the composite nanoparticle is about 120 nm. The drug release process proves the feasibility of this preparation method. |
| Key words: magnetic fluids magnetic target system 10-Hydroxycamptothecin the release of drugs |
